[临床研究]清热活血方药改善活动期类风湿关节炎湿热瘀阻证临床症状的研究

Time:2016-02-21 22:56:40 来源:100053 北京,中国中医科学院广安门医院风湿病科 等 作者:焦娟 姜泉 曹炜 唐晓颇

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R]

卷: 33 期数: 2011年10期

页码: 872-875

栏目: 临床研究

出版日期: 2011-10-30

文章信息/Info

Title: Study on Qingre-Huoxue Recipe in improving clinical symptoms of dampness-heat and blood-stasis syndrome of rheumatoid arthritis

作者: 焦娟 姜泉 曹炜 唐晓颇 100053 北京,中国中医科学院广安门医院风湿病科

Author(s): JIAO Juan;  JIANG Quan;  CAO Wei;  TANG Xiao-po Rheumatism Dept. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing100053, China

关键词: 清热活血方药; 湿热瘀阻证; 类风湿关节炎

Keywords: Qingre-Huoxue Recipe; Dampness-heat and blood-stasis syndrome; Rheumatoid arthritis

DOI: 10.3760/cma.j.issn.1673-4246.2011.10.003

文献标志码: A

摘要: 目的 比较清热活血方药(中药组)和清热活血方药联合甲氨蝶呤片(中药+MTX组)改善类风湿关节炎(RA)湿热瘀阻证临床症状的有效性和安全性。方法 采用随机多中心平行对照试验设计,将142例湿热瘀阻证RA患者随机分为中药组71例和中药+MTX组71例,以临床症状/体征为疗效评价指标,观察期为12周,采用全数据集(FAS)和符合方案数据集(PP)进行统计分析。结果 两组均可减轻关节疼痛[分别为(4.82±1.98)分、(4.31±1.85)分],减少关节压痛数[分别为(8.72±6.24)个、(7.14±5.03)个]及肿胀数[分别为(4.87±4.05)个、(4.20±3.36)个]、缩短晨僵时间[分别为[(39.56±46.68)min、(36.65±42.58)min],并可减轻疲乏症状[分别为(4.13±2.34)分、(3.74±2.20)分],且安全性较好,但组间比较差异无统计学意义(P>0.05)。结论 在改善湿热瘀阻证RA患者临床症状方面,中药+MTX组较中药组无明显疗效优势。但清热活血方药可较好改善湿热瘀阻证RA患者的临床症状。

Abstract: Objective To Evaluate the efficacy and safety of Qingre-Huoxue Recipe(QHR), Qingre -Huoxue Recipe and Methotrexate(QHR+MTX) in improving clinical symptoms of dampness-heat and blood-stasis syndrome of rheumatoid arthritis. Methods According to multi-center, randomized, and control intervention design, 142 RA patients were randomly divided into QHR group(71 cases)and QHR+MTX group(71 cases). With clinical symptoms as evaluation indexes, FAS set and PP set were adapted for analysis. Results FAS set analysis: Both groups can significantly reduce pain VAS score[(4.82±1.98)vs(4.31±1.85)], reduce tenderness and swollen joint number[(4.87±4.05)vs(4.20±3.36)、(8.72±6.24)vs(7.14±5.03) respectively], shorten morning stiffness[(39.56±46.68)min vs(36.65±42.58)min] and significantly reduce the symptoms of fatigue[(4.13±2.34) vs (3.74±2.20)], also with good security. But there was no statistically significant difference between the two groups. Conclusion Qingre-Huoxue Recipe with MTX had no significant advantage in improving clinical symptoms in patients with the dampness-heat and blood-stasis syndrom of RA than without MTX.

参考文献/References:

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