[临床研究]蠲痹颗粒用于寒湿痹阻和肾气虚寒型类风湿关节炎的临床疗效观察

Time:2016-02-21 23:46:13 来源:402560 重庆医科大学中医药学院附属铜梁中医院风湿病科 等 作者:崔世奎

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R]

卷: 34 期数: 2012年02期

页码: 122-125

栏目: 临床研究

出版日期: 2012-02-29

文章信息/Info

Title: Clinical study on treatment of rheumatoid arthritis of cold dampness obstruction and kidney yang qi deficiency with Juanbi granulae

作者: 崔世奎 402560 重庆医科大学中医药学院附属铜梁中医院风湿病科

Author(s): CUI Shi-kui TCM Hospital Affiliated to College of Traditional Chinese Medicine Chongqing University of Medical Sciences(Department of Rheumatology), Tongliang 402560, China

关键词: 蠲痹颗粒; 寒湿痹阻型和肾气虚寒型; 类风湿关节炎

Keywords: Juanbi granulae; Cold dampness obstruction and kidney yang qi deficiency syndrome; Rheumatoid arthritis

DOI: 10.3760/cma.j.issn.1673-4246.2012.02.009

摘要: 目的 初步评价蠲痹颗粒对寒湿痹阻和肾气虚寒型类风湿关节炎(rheumatoid arthritis,RA)的临床疗效。方法 采用随机数字表法将全部RA患者随机分为治疗组80例,对照组40例。全部患者均口服甲氨蝶呤片,10 mg/次,1次/周。治疗组在此基础上口服蠲痹颗粒,15 g/次,3次/d;对照组口服正清风痛宁缓释片,60 mg/次,2次/d。两组均治疗4周后统计疗效。结果 ①治疗组疗效总有效率为95.0%、对照组为85.0%,两组比较差异有统计学意义(U=-4.071,P<0.05);治疗组证候疗效总有效率为72.5%、对照组为37.5%,两组比较差异有统计学意义(U=-3.232,P<0.05)。②同组间疗效及证候疗效比较,差异均有统计学意义[(疾病疗效总有效率分别为100.0%、86.7%,U值分别为-5.50、-3.67,P<0.01或0.05);(证候疗效总有效率分别为88.0%、80.0%,U值分别为-2.909、-3.992,P均<0.05)]。③治疗后治疗组在改善ESR(17.05±7.15)mm/h、RF(32.46±14.22)U/L方面优于对照组(P均<0.05)。结论 蠲痹颗粒治疗寒湿痹阻和肾气虚寒型RA疗效确切,其中寒湿痹阻型RA疗效更明显。

Abstract: Objective To observe the effect of Juanbi granulae on rheumatoid arthritis belonging to cold dampness obstruction and kidney yang qi deficiency syndrome. Methods All 120 RA patients in accordance with the inclusion criteria were divided into a 80 cases of study group, and a 40 cases of control group, by random table method. Methotrexate, 10mg once a week,was given orally, as a basis for treatment. The treatment group given Juanbi granulae, 15g for each time, 3 times a day; while the control group was Zhenqingfengtongning sustained-release tablets, 60mg for each time , twice daily. Both groups have adopted a one-month course of treatment. Statistics effect was evaluated after 4-week course of treatment. Results ① There was significant difference between the two group in terms of therapeutic effects and symptom effects after the treatment (the total effective rate of study group and control group was 100.0%, 86.7%, U value was-4.071, -3.232 respectively, P<0.05). ② The treatment effects and the symptom effect of the cold dampness syndrome and the kidney yang qi deficiency syndrome in the same group showed statistical difference after the treatment (the total effective rate of study group and control group was 88.0%, 80.0%,The U value of treatment effect was-5.50, -3.67 respectively, P<0.01 or P<0.05). (U value of syndrome effect was-2.909, -3.992 respectively, P<0.05). ③ Study group of after treatment ESR(17.05±7.15)mm/h, RF(32.46±14.22)U/L, compared with the control group of after treatment, the difference was statistically significant (P<0.05). Conclusion Juanbi granulae was effective in treating rheumatoid arthritis of both kidney yang qi deficiency syndrome and cold dampness obstruction syndrome, the effects were especially better for cold dampness obstruction syndrome.

参考文献/References:

[1] 郑筱萸. 中药新药临床研究指导原则(试行). 北京:中国医药科技出版社,2002.
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