[临床研究]乌梅丸用于寒热错杂型腹泻型肠易激综合征的疗效评价

Time:2016-02-21 23:59:41 来源:324000 浙江省衢州市人民医院中医科(叶涛);100053 北京,中国中医科学院广安门医院脾胃病科(陶夏平) 等 作者:叶涛 陶夏平

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R]

卷: 35 期数: 2013年08期

页码: 689-691

栏目: 临床研究

出版日期: 2013-08-05

文章信息/Info

Title: Curative effect evaluation on 46 cases of cold-heat complex diarrhea type irritable bowel syndrome treated with Wumei pill

作者: 叶涛 陶夏平 324000 浙江省衢州市人民医院中医科(叶涛);100053 北京,中国中医科学院广安门医院脾胃病科(陶夏平)

Author(s): YE Tao;  TAO Xia-ping Guang’anmen hospitol China Academy of Chinese Medical Sciences,Gastroenterology department, Beijing, 100053, China

关键词: 肠易激综合征; 寒热错杂; 乌梅丸

Keywords: Irritable bowel syndrome; Cold-heat complex; Wumei Pill

DOI: DOI:10.3760/cma.j.issn.1673-4246.2013.08.006

摘要: 【摘要】 目的 观察乌梅丸治疗寒热错杂型肠易激综合征(腹泻型)的临床疗效。方法 收集2009年1月至2011年12月中国中医科学院广安门医院门诊患者,对符合中医寒热错杂证诊断标准、西医肠易激综合征(腹泻型)诊断标准的46例患者,均予乌梅丸加减方治疗,分别观察大便次数、大便性状、腹痛不适、肠鸣、畏寒怕冷5种主要症状。并对治疗前、治疗后1周、2周及4周进行症状积分评价。结果 治疗后1周、2周及4周时患者总有效率分别为58.70%(27/46)、84.78%(39/46)、97.83%(45/46),其中总有效率治疗后2周与治疗后1周比较,治疗后4周与治疗后2周比较,治疗后4周与治疗后1周比较,差异均有统计学意义(治疗2周与治疗1周比χ2=8.571;治疗4周与治疗2周比χ2=16.426;治疗4周与治疗1周比χ2=35.622,P均<0.05)。治疗后4周大便次数、大便性状、腹痛不适、肠鸣、畏寒怕冷有效率分别为82.05%(32/39)、95.56%(43/45)、92.86%(39/42)、85.71%(18/21)、64.29%(27/42),与治疗后1周比较,差异有统计学意义(大便次数χ2=7.123、大便性状χ2=13.611、腹痛不适χ2=7.721、肠鸣χ2=10.096、畏寒怕冷χ2=10.769,P均<0.05)。结论 乌梅丸治疗寒热错杂型肠易激综合征(腹泻型)疗效确定

Abstract: 【Abstract】 Objective To observe the clinical curative effect of Wumei Pill in the treatment of cold-heat complex diarrhea-predominant irritable bowel syndrome. Methods Modified Wumei Pill was adopted to treat 46 cases of cold-heat complex diarrhea predominant irritable bowel syndrome. Five main symptoms of stool frequency, stool shape and properties, abdominal pain and discomfort, bowel gurgling, vulnerable to the cold were observed. The symptom scores before the treatment and 1 week, 2 weeks and 4 weeks after the treatment were evaluated. Results After the treatment of 1 week, 2 weeks and 4 weeks, the overall efficiency was 58.70%(27/46), 84.78%(39/46), and 97.83%(45/46) respectively, and there were significant differences in curative effect between the different treatment courses(between treatment of 2 weeks and 1 week χ2=8.571,between treatment of 4 weeks and 2 week χ2=16.426,between treatment of 4 weeks and 1 week χ2=35.622). Effective rate of symptoms after 4 weeks treatment were respectively: stool frequency 82.05%(32/39), stool shape and properties 95.56%(43/45), abdominal pain and discomfort 92.86%(39/42),bowel gurgling 85.71%(18/21), vulnerable to the cold 64.29%(27/42), and there was obvious differences in effective percentage of five kinds of symptoms between treatment of 4 weeks and 1 week(Stool frequency χ2=7.123、stool shape and properties χ2=13.611、abdominal pain or discomfort χ2=7.721、bowel gurgling χ2=10.096、vulnerable to the cold χ2=10.769). Conclusion . The clinical effect of Wumei Pill for the treatment of cold-heat complex diarrhea predominant irritable bowel syndrome was defined.

参考文献/References:

[1] 中华医学会消化病学分会胃肠动力学组. 肠易激综合征诊断和治疗的共识意见. 中华消化杂志,2008,28(1):38-40.
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