[论著]宁泌泰胶囊联合托特罗治疗经尿道前列腺电切术后膀胱过度活动症临床研究

Time:2016-02-22 00:42:34 来源:054000邢台,河北省民政总医院泌尿外科等 作者:贾民 张晓宇 刘铄 胡胜平

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R]

卷: 37 期数: 2015年08期

页码: 695-698

栏目: 论著

出版日期: 2015-08-05

文章信息/Info

Title: The clinical efficacy of Ningmitai capsule combined with tolterodine in the treatment of overactiver bladder after transurethral resection of the prostate

作者: 贾民 张晓宇 刘铄 胡胜平 054000邢台,河北省民政总医院泌尿外科

Author(s): Jia Min' target="_blank" rel="external"> Jia Min;  Zhang Xiaoyu;  Liu Shuo; ' target="_blank" rel="external"> Hu Shengping. Department of Urology, Hebei Province Civil Affairs General Hospital, Xingtai 054000, China

关键词: 前列腺增生; 膀胱; 逼尿过度; 经尿道前列腺切除术; 宁泌泰胶囊; 托特罗定

Keywords: Prostatic hyperplasia;  Urinary bladder;  overactive;  Transurethral resection of the prostate;  Ningmitai capsule;  Tolterodine

DOI: 10.3760/cma.j.issn.1673-4246.2015.08.007

摘要: 目的 评价宁泌泰胶囊联合托特罗定治疗经尿道前列腺电切术(transurethral resection of prostate, TURP)后膀胱过度活动症(overactive bladder, OAB)的临床疗效。方法 将符合纳入标准的63例TURP术后合并OAB患者采用随机数字法分为联合组32例和对照组31例,对照组于手术当日起口服托特罗定片,联合组于手术当日起加服宁泌泰胶囊,全部患者均拔除尿管后5 d停药。观察2组患者TURP术后置管期间膀胱痉挛伴疼痛次数、持续时间及自主排尿期内的每次尿量、急迫性尿失禁次数、平均每日尿急次数、OABSS评分并判定疗效。结果 联合组在术后第1天[(3.5±0.5)次比(4.4±0.8)次,t=2.650]、第2天[(1.5±0.9)次比(1.8±0.2)次,t=2.350]和第3天[(0.4±1.6)比(1.1±1.8)次,t=2.210]膀胱痉挛次数,24 h内膀胱痉挛总持续时间[(78.3±6.2)次比(95.5±6.1)次,t=1.270]均少于对照组,但组间比较差异均无统计学意义(P>0.05)。联合组在术后拔除尿管后5 d平均24 h排尿次数[(6.2±1.3)次比(9.4±1.8)次,t=2.710]平均夜尿次数[(1.5±0.4)次比(3.9±1.0)次,t=2.580]、平均24 h尿急次数[(1.1±0.3)次比(3.2±0.8)次,t=2.660]、平均24 h尿失禁次数[(0.5±0.2)次比(2.4±0.6)次,t=2.700]及OABSS总评分[(4.6±1.2)分比(6.9±2.1)分,t=2.470]均优于对照组(P<0.05)。结论 宁泌泰胶囊联合托特罗定用于TURP术后OAB的治疗,疗效优于单用托特罗定片,有助于患者恢复,提高其生活质量。

Abstract: Objective To observe the clinical efficacy of Ningmitai capsule combined with Tolterodine in the treatment of overactiver bladder after transurethral resection of the prostate(TURP). Methods 63 TURP patients with bladder disease (OAB) in our hospital from October 2012 to October 2012 were selected and randomly divided into a treatment group (n=32) and a control group (n=31). From the date of operation, the control group was treated with tolterodine 2 mg, 2 times a day, while the treatment group was additional treated with Ningmitai capsule 4mg, 3 times a day based on the control group. All patients stopped to take medicine 5 days after catheter removal. The pain frequency and duration of bladder spasm after TURP in catheterization period and the urine volume per time, the number of urgent incontinence, and the number of urgent micturition average day in automatic micturition period were scored by OABSS. Results The number of bladder spasm in the first postoperative day(3.5 ± 0.5 vs. 4.4 ± 0.8,t=2.650), the second day(1.5 ± 0.9 vs. 1.8 ± 0.2, t=2.350) and the third day (0.4 ± 1.6 vs. 1.1 ± 1.8, t=2.210) of the treatment group were all less than the control group (P>0.05). The 24 h average frequency of urination after catheter removal (6.2 ± 1.3 vs. 9.4 ± 1.8, t=2.710), the average number of nocturia (1.5 ± 0.4 vs. 3.9 ± 1.0, t=2.580), the average number of 24h urinary urgency (1.1 ± 0.3 vs. 3.2 ± 0.8, t=2.660), the average number of incontinence in 24 h (0.5 ± 0.2 vs. 2.4 ± 0.6, t=2.700) and OABSS total score (4.6 ± 1.2 vs. 6.9 ± 2.1, t=2.470) of the treatment group were all better than the control group (P<0.05). Conclusion Ningmitai capsule combined with tolterodine in the treatment of overactiver bladder after TURP has significant clinical effect, helping patients recovery and improving quality of life.

参考文献/References:

[1] Peters TJ,Donovan JL,Kay HE,et al. The International Continence Society“Benign Prostatic Hyperplasia”Study:The bothersomeness of urinary symptoms[J]. J Urol,1997,157(3): 885-889.

[2] Homma Y,Yoshida M,seki N,et al. Symptom assessment tool for overactive bladder syndrome-overactive bladder symptom score[J]. Urology,2006,68(2):318-323.

[3] 金锡御,宋波,杨勇,等. 膀胱过度活动症临床指导原则[J]. 中华泌尿外科杂志,2002,23(5):311-313.

[4] 那彦群,叶章群,孙光. 中国泌尿外科疾病诊断治疗指南[M]. 北京:人民卫生出版杜,2011:223.

[5] 方雪峰,黄朝荣,高永生,等. 经尿道电切联合汽化电切治疗前列腺增生症(附64侧报告)[J]. 中国内镜杂志,2004, 10(1):92-93,95.

 1/2    1 2 下一页 尾页

本文来自网络,不能作为诊断及医疗的依据,不代表本网站立场,版权归原作者所有。

 进入论坛讨论

内容声明

本网站所有注明“来源:中医园”的文字、图片和音视频资料,版权均属于中医园所有,任何媒体、网站或个人转载时须注明“来源:中医园”。本网所有转载文章系出于传递更多信息之目的,一般都来源于网络分享,不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理,同时内容不能作为诊断及医疗的依据,不代表本网站立场。