[论著]滑膜炎颗粒抗炎作用的实验研究

Time:2016-02-22 19:46:38 来源:051430石家庄,河北省中药注射剂新药开发技术国家地方联合工程实验室(张志伟、邢云涛、董倩);100700 北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心(孙丽华、周艳华、崔海峰、孙明杰);051430石家庄,神威药业集团有限公司(李志刚、李振江);051430石家庄,河北省中药注射液工程技术研究中心(逯蕴、张华健)等 作者:张志伟 孙丽华 周艳华 崔海峰 孙明杰 李志刚 邢云涛 董倩

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R]

卷: 37 期数: 2015年07期

页码: 621-625

栏目: 论著

出版日期: 2015-07-10

文章信息/Info

Title:

Experimental study on anti-inflammatory effects of Huamoyan granules

作者: 张志伟 孙丽华 周艳华 崔海峰 孙明杰 李志刚 邢云涛 董倩 逯蕴 张华健 李振江

051430石家庄,河北省中药注射剂新药开发技术国家地方联合工程实验室(张志伟、邢云涛、董倩);100700 北京市中医药防治重大疾病基础研究重点实验室,中国中医科学院医学实验中心(孙丽华、周艳华、崔海峰、孙明杰);051430石家庄,神威药业集团有限公司(李志刚、李振江);051430石家庄,河北省中药注射液工程技术研究中心(逯蕴、张华健)

Author(s): Zhang Zhiwei' target="_blank" rel="external">

Zhang Zhiwei*;  Sun Lihua;  Zhou Yanhua' target="_blank" rel="external"> Zhou Yanhua;  Cui Haifeng;  Sun Mingjie;  Li Zhigang;  Xing Yuntao;  Dong Qian;  Lu Yun;  Zhang Huajian; 

' target="_blank" rel="external"> Li Zhenjiang.

* State and Local Area Jointed Laboratory of Engineering for New Drug Development Technology of TCM Injection, Shijiazhuang 051430, China

关键词:

punctuation-wrap: simple">滑膜炎颗粒; 抗炎作用; ' target="_blank" rel="external">实验研究

Keywords:

punctuation-wrap: simple"> Huamoyan granules;  Anti-inflammation effects ; ' target="_blank" rel="external"> Experimental study

DOI: 10.3760/cma.j.issn.1673-4246.2015.07.012

摘要:

目的 探讨滑膜炎颗粒对急、慢性炎症的抗炎作用。方法 按随机数字表法将50只昆明小鼠和150只SD大鼠分别分为模型组,布洛芬组,滑膜炎颗粒高、中、低剂量组。布洛芬组灌胃布洛芬溶液,小鼠给药剂量为0.13 g/kg,大鼠给药剂量为0.093 g/kg;滑膜炎颗粒高、中、低剂量组灌胃滑膜炎颗粒溶液,小鼠给药剂量分别为12、6、3 g/kg,大鼠给药剂量为8.4、4.2、2.1 g/kg;模型组灌胃等体积蒸馏水,给药1次/d,连续给药3 d或10 d。采用醋酸致小鼠腹腔毛细管通透性亢进法、大鼠足跖蛋清致肿法和大鼠足跖角叉菜胶致肿法观察滑膜炎颗粒对急性炎症的抗炎作用;大鼠棉球肉芽肿法观察滑膜炎颗粒对慢性增殖性炎症的抗炎作用。结果 与模型组比较,布洛芬组,滑膜炎颗粒高、中剂量组对醋酸致小鼠腹腔毛细血管通透性亢进有抑制作用[(0.185±0.046)、(0.177±0.055)、(0.190±0.052)比(0.246±0.050),P<0.05或P<0.01];在致炎后0.5、1、2、4、6 h,滑膜炎颗粒高剂量组可抑制蛋清所致大鼠的足肿胀,足肿胀抑制率分别为22.46%、19.20%、24.32%、33.75%、24.19%;致炎后4、6 h,布洛芬组、滑膜炎颗粒高剂量组可明显抑制角叉菜胶致的大鼠足肿胀度,足肿胀抑制率分别为32.05%、30.56%和19.23%、20.83%。结论 滑膜炎颗粒对急性、早期炎症具有明显的抗炎作用。

Abstract:

Objective The purpose of this study was to investigate the anti-inflammatory effects on acute and chronic inflammation of Huamoyan Granules(HMYG). Methods KM mice and SD rats were randomly divided into model group, ibuprofen group and HMYG high, midpe and low three dosages groups. The Ibuprofen group was administrated drug by gavage, mice 0.13 g/kg and rats 0.093 g/kg. The HMYG groups were administrated orally, mice 12, 6 and 3g/kg, rats 4, 4.2 and 2.1 g/kg. The model group was given the same volume distilled water, once a day, 3 or 10 continuous days. The increased permeability of mice abdominal capillary was induced by acetic acid, edema of rat hind paw was induced by albumen and carrageenin, which both were adopted to observe the acute anti-inflammatory effects; and cotton pellet granuloma was to observe the chronic anti- inflammation effects of HMYG. Results Compared with the model group, the ibuprofen group, the HMYG high and midpe group showed anti-inflammatory actions of mice induced by acetic acid (0.185 ± 0.046, 0.177 ± 0.055, 0.190 ± 0.052 vs. 0.246 ± 0.050,P<0.05 or P<0.01); after 0.5, 1, 2, 4 and 6 hrs inflammation, HMYG high dosage group had significant inhibition for the edema of rats hind paw induced by albumen model, the inhibitory rate was 22.46%, 19.20% and 24.32%, 33.75%, 24.19%; 4 and 6 hrs after inflammation, HMYG high dosage group could reduce rats paw edema induced by carrageenin, the inhibitory rate was 32.05%, 30.56% and 19.23%, 20.83%. Conclusion HMYG has evident anti-inflammatory effects on acute inflammation.

参考文献/References:

[1] 雷鹏飞,谢杰,文霆,等. 膝关节置换与关节镜治疗膝关节色素沉着绒毛结节性滑膜炎[J]. 中国组织工程研究,2013, 17(52):9077-9082.

[2] 朱翔,董扬. 膝关节滑膜炎性病变临床特征、诊断和治疗[J]. 国际骨科学杂志,2011,32(1):65-68.

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